2026-04-17T05:50:24Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1834892026-02-03T19:03:29Zcom_2072_1057col_2072_478858col_2072_478906col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Oltra González, Javier author Campabadal Delgado, Anna author Segura i Fàbregas, Bàrbara author Uribe, Carme author Martí Domènech, Ma. Josep author Compta, Yaroslau author Valldeoriola Serra, Francesc author Bargalló Alabart, Núria author Iranzo, Alex author Junqué i Plaja, Carme, 1955- author 2022-02-24T15:51:36Z 2022-02-24T15:51:36Z 2021-12-21 2022-02-24T15:51:36Z Recent studies associated rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease (PD) with severe cognitive impairment and brain atrophy. However, whole-brain functional connectivity has never been explored in this group of PD patients. In this study, whole-brain network-based statistics and graph-theoretical approaches were used to characterize resting-state interregional functional connectivity in PD with probable RBD (PD-pRBD) and its relationship with cognition. Our sample consisted of 30 healthy controls, 32 PD without probable RBD (PD-non pRBD), and 27 PD-pRBD. The PD-pRBD group showed reduced functional connectivity compared with controls mainly involving cingulate areas with temporal, frontal, insular, and thalamic regions (p < 0.001). Also, the PD-pRBD group showed reduced functional connectivity between right ventral posterior cingulate and left medial precuneus compared with PD-non pRBD (p < 0.05). We found increased normalized characteristic path length in PD-pRBD compared with PD-non pRBD. In the PD-pRBD group, mean connectivity strength from reduced connections correlated with visuoperceptual task and normalized characteristic path length correlated with processing speed and verbal memory tasks. This work demonstrates the existence of disrupted functional connectivity in PD-pRBD, together with abnormal network integrity, that supports its consideration as a severe PD subtype. Malaltia de Parkinson Cervell Parkinson's disease Brain Disrupted functional connectivity in PD with probable RBD and its cognitive correlates