2026-04-13T02:02:27Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1834672025-12-04T19:31:25Zcom_2072_1057col_2072_478908col_2072_478917
RECERCAT
author
Calon, Alexandre
author
Espinet, Elisa
author
Palomo Ponce, Sergio
author
Tauriello, Daniele V. F.
author
Iglesias, Mar
author
Cespedes, María Virtudes
author
Sevillano, Marta
author
Nadal, Cristina
author
Jung, Peter
author
Zhang, Xiang H. F.
author
Byrom, Daniel
author
Riera i Escalé, Antoni
author
Rossell, David
author
Mangues, Ramon
author
Massagué i Solé, Joan, 1953-
author
Sancho, Elena
author
Batlle, Eduard
2022-02-24T19:00:57Z2022-02-24T19:00:57Z2014-03-052022-02-24T12:05:43Z
We sought to understand the mechanisms behind the potent effect of stromal TGF-beta program on the capacity of colorectal cancer (CRC) cells to initiate metastasis. We discovered that mice subcutaneous tumors and metastases generated in the context of a TGF-beta activated microenvironment displayed prominent accumulation of p-STAT3 in CRC cells compared with those derived from control cells. STAT3 signaling depended on GP130 as shown by strong reduction of epithelial p STAT3 levels upon GP130 shRNA-mediated knockdown in CRC cells.
(c) Bio-protocol LLC, 2014 info:eu-repo/semantics/openAccess
Càncer colorectal
Metàstasi
Expressió gènica
Colorectal cancer
Metastasis
Gene expression
Immunostaining Protocol: P-Stat3 (Xenograft and Mice)
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion