2026-04-13T13:30:52Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1833472025-12-04T19:37:48Zcom_2072_1057col_2072_478813col_2072_478917
RECERCAT author Garcia, Xavier author Sabaté, Maria del Mar author Aubets, Jorge author Jansat, Josep Ma author Sentellas, Sonia 2022-02-21T15:39:00Z2022-02-21T15:39:00Z2021-03-012022-02-21T15:39:00Z This paper aims to cover the main strategies based on ion mobility spectrometry (IMS) for the analysis of biological samples. The determination of endogenous and exogenous compounds in such samples is important for the understanding of the health status of individuals. For this reason, the development of new approaches that can be complementary to the ones already established (mainly based on liquid chromatography coupled to mass spectrometry) is welcomed. In this regard, ion mobility spectrometry has appeared in the analytical scenario as a powerful technique for the separation and characterization of compounds based on their mobility. IMS has been used in several areas taking advantage of its orthogonality with other analytical separation techniques, such as liquid chromatography, gas chromatography, capillary electrophoresis, or supercritical fluid chromatography. Bioanalysis is not one of the areas where IMS has been more extensively applied. However, over the last years, the interest in using this approach for the analysis of biological samples has clearly increased. This paper introduces the reader to the principles controlling the separation in IMS and reviews recent applications using this technique in the field of bioanalysis. cc-by (c) Garcia, Xavier et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Espectroscòpia de mobilitat d'ions Espectrometria de masses Ion mobility spectroscopy Mass spectrometry Ion mobility-Mass spectrometry for bioanalysis info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion