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Adrenergic Modulation With Photochromic Ligands Prischich, Davia Giralt Lledó, Ernest Hernando, Jordi Guasch i Casany, Eduard Meana, J. Javier Villa, Pedro de la Gorostiza Langa, Pablo Ignacio Gomila Juaneda, Alexandre Milla Navarro, Santiago Sangüesa Puigventós, Gemma Diez Alarcia, Rebeca Preda, Beatrice Matera, Carlo Batlle, Montserrat Neurotransmissors Receptors adrenèrgics Neurotransmitters Adrenaline receptors © 2020 Wiley-VCH GmbH Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio-temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability, and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice. 2022-02-16T13:58:24Z 2022-02-16T13:58:24Z 2021-02-15 2022-02-16T06:39:24Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 1521-3773 https://hdl.handle.net/2445/183210 6467569 33103317 eng Postprint del document publicat a: https://doi.org/10.1002/anie.202010553 Angewandte Chemie, 2021, vol 60, num 7, p. 3625-3631 https://doi.org/10.1002/anie.202010553 info:eu-repo/grantAgreement/EC/H2020/945539/EU//HBP SGA3 (c) Wiley-VCH, 2021 info:eu-repo/semantics/openAccess 7 p. application/pdf John Wiley and Sons Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))