2026-04-17T04:23:14Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1830842025-12-05T14:13:01Zcom_2072_1057col_2072_478815col_2072_478917

00925njm 22002777a 4500 dc Fernandes, Ana Rita author Sánchez-López, E. (Elena) author Santini, Antonello author Dos Santos, Tiago author García López, María Luisa author Silva, Amélia M. author Souto, Eliana B. author 2022-02-11T11:09:54Z 2022-02-11T11:09:54Z 2021-10-01 2022-02-11T11:09:54Z Oil-in-water nanoemulsions (NEs) are considered a suitable nanotechnological approach to improve the eye-related bioavailability of lipophilic drugs. The potential of cationic NEs is prominent due to the electrostatic interaction that occurs between the positively charged droplets with the negatively charged mucins present in the tear film. This interaction offers prolonged NEs residence at the ocular surface, increasing the drug absorption. Triamcinolone acetonide (TA) is one of the first pharmacologic strategies applied as an intravitreal injection in the treatment of age-related macular degeneration (AMD). Newly synthesized quaternary derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO) and quinuclidine surfactants have been screened with the purpose to select the best compound to formulate long-term stable NEs that combine the best physicochemical properties for the loading of TA intended for ocular administration Agents tensioactius Nanofluids Farmacologia ocular Surface active agents Nanofluids Ocular pharmacology Mono-and dicationic dabco/quinuclidine composed nanomaterials for the loading of steroidal drug: 32 factorial design and physicochemical characterization