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oai:recercat.cat:2445/1829682025-11-19T22:41:04Zcom_2072_1057col_2072_478917

Naturally Acquired Humoral Immunity against Malaria Parasites in Non-Human Primates from the Brazilian Amazon, Cerrado and Atlantic Forest. Ferreira Monteiro, Eliana Fernández Becerra, Carmen Silva Araujo, Maisa da Rezende Messias, Mariluce Shozo Ozaki, Luis Ribeiro de Castro Duarte, Ana Maria Galvao Bueno, Marina Catao Dias, Jose Luiz Romeiro Fernandes Chagas, Carolina Silva Mathias, Bruno da Gomes dos Santos, Mayra Santos, Stéfanie Vanessa Moreira Holcman, Marcia Souza, Julio Cesar de Jr. Kirchgatter, Karin Malària Immunitat Malaria Immunity Plasmodium - Plasmodium brasilianum - P. malariae - P. malariae - P. falciparum - P. vivax - Plasmodium content: - "Non-human primates (NHPs) have been shown to be infected by parasites of the genus " - ", the etiological agent of malaria in humans, creating potential risks of zoonotic transmission. " - ", a parasite species similar to " - " of humans, have been described in NHPs from Central and South America, including Brazil. The merozoite surface protein 1 (MSP1), besides being a malaria vaccine candidate, is highly immunogenic. Due to such properties, we tested this protein for the diagnosis of parasite infection. We used recombinant proteins of " - " MSP1, as well as of " - " and " - ", for the detection of antibodies anti-MSP1 of these parasite species, in the sera of NHPs collected in different regions of Brazil. About 40% of the NHP sera were confirmed as reactive to the proteins of one or more parasite species. A relatively higher number of reactive sera was found in animals from the Atlantic Forest than those from the Amazon region, possibly reflecting the former more intense parasite circulation among NHPs due to their proximity to humans at a higher populational density. The presence of " - " positive NHPs in the surveyed areas, being therefore potential parasite reservoirs, needs to be considered in any malaria surveillance program." 2022-02-07T08:49:28Z 2022-02-07T08:49:28Z 2020 2022-02-04T19:00:44Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: http://dx.doi.org/ 10.3390/pathogens9070525 Pathogens, 2020, vol 9, num 7 http://dx.doi.org/ 10.3390/pathogens9070525 cc by (c) Ferreira Monteiro, Eliana et al, 2020 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess MDPI AG Articles publicats en revistes (ISGlobal)