2026-04-17T00:45:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1823212026-01-14T12:11:49Zcom_2072_1057col_2072_478916col_2072_478917col_2072_478929

00925njm 22002777a 4500 dc Olivan Riera, Mireia author Garcia, Marta author Suárez, Leticia author Guiu, Marc author Gros, Laura author Méndez, Olga author Rigau, Marina author Reventós Puigjaner, Jaume author Segura, Miguel F. author Torres, Inés de author Planas, Jacques author Cruz, Xavier de la author Gomis i Cabré, Roger author Morote, Juan author Rodríguez Barrueco, Ruth author Santamaria Margalef, Anna author 2022-01-13T18:50:09Z 2022-01-13T18:50:09Z 2021-12-09 2022-01-13T13:08:14Z About 70% of advanced-stage prostate cancer (PCa) patients will experience bone metastasis, which severely affects patients' quality of life and progresses to lethal PCa in most cases. Hence, understanding the molecular heterogeneity of PCa cell populations and the signaling pathways associated with bone tropism is crucial. For this purpose, we generated an animal model with high penetrance to metastasize to bone using an intracardiac percutaneous injection of PC3 cells to identify PCa metastasis-promoting factors. Using genomic high-throughput analysis we identified a miRNA signature involved in bone metastasis that also presents potential as a biomarker of PCa progression in human samples. In particular, the downregulation of miR-135b favored the incidence of bone metastases by significantly increasing PCa cells' migratory capacity. Moreover, the PLAG1, JAKMIP2, PDGFA, and VTI1b target genes were identified as potential mediators of miR-135b's role in the dissemination to bone. In this study, we provide a genomic signature involved in PCa bone growth, contributing to a better understanding of the mechanisms responsible for this process. In the future, our results could ultimately translate into promising new therapeutic targets for the treatment of lethal PCa. Càncer de pròstata Metàstasi Marcadors bioquímics Prostate cancer Metastasis Biochemical markers Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples