2026-04-17T04:19:32Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1813212025-12-05T12:02:54Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Ciudin, Andreea author Fidilio, Enzamaria author Gutiérrez Carrasquilla, Liliana author Caixàs i Pedragós, Assumpta author Vilarrasa, Nuria author Pellitero, Silvia author Simó Servat, Andreu author Vilallonga, Ramon author Ruiz, Amador author Fuente, Maricruz de la author Luna, Alexis author Sánchez, Enric author Rigla, Mercedes author Hernández Munain, Cristina author Salas, Eduardo author Simó, Rafael author Lecube, Albert author 2021-11-18T14:34:50Z 2021-11-18T14:34:50Z 2021-10-17 2021-11-18T10:37:54Z Around 30% of the patients that undergo bariatric surgery (BS) do not reach an appropriate weight loss. The OBEGEN study aimed to assess the added value of genetic testing to clinical variables in predicting weight loss after BS. A multicenter, retrospective, longitudinal, and observational study including 416 patients who underwent BS was conducted (Clinical.Trials.gov- NCT02405949). 50 single nucleotide polymorphisms (SNPs) from 39 genes were examined. Receiver Operating Characteristic (ROC) curve analysis were used to calculate sensitivity and specificity. Satisfactory response to BS was defined as at nadir excess weight loss >50%. A good predictive model of response [area under ROC of 0.845 (95% CI 0.805-0.880), p < 0.001; sensitivity 90.1%, specificity 65.5%] was obtained by combining three clinical variables (age, type of surgery, presence diabetes) and nine SNPs located in ADIPOQ, MC4R, IL6, PPARG, INSIG2, CNR1, ELOVL6, PLIN1 and BDNF genes. This predictive model showed a significant higher area under ROC than the clinical score (p = 0.0186). The OBEGEN study shows the key role of combining clinical variables with genetic testing to increase the predictability of the weight loss response after BS. This finding will permit us to implement a personalized medicine which will be associated with a more cost-effective clinical practice. Obesitat Genètica Cirurgia Obesity Genetics Surgery A Clinical-Genetic Score for Predicting Weight Loss after Bariatric Surgery: The OBEGEN Study