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oai:recercat.cat:2445/1810542025-12-05T12:13:16Zcom_2072_1057col_2072_478916col_2072_478917

Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly Pegueroles, Jordi Pané, Adriana Vilaplana, Eduard Montal, Victor Bejanin, Alexandre Videla, Laura Carmona Iragui, María Barroeta, Isabel Ibarzabal, Ainitze Casajoana, Anna Alcolea, Daniel Valldeneu, Silvia Altuna, Miren Hollanda Ramírez, Ana M. de Vidal i Cortada, Josep Ortega Martínez de Victoria, Emilio Osorio, Ricardo Convit, Antonio Blesa González, Rafael Lleó Bisa, Alberto Fortea Ormaechea, Juan Jiménez Pineda, Amanda Alzheimer's Disease Neuroimaging Initiative Obesitat Demència Obesity Dementia Aims/hypothesis: Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. Methods: We selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (Aβ)1-42, p-tau, and t-tau levels. We performed regression analyses between these biomarkers and body mass index (BMI). Results: We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m2). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. Conclusions/interpretation: In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology. 2021-11-04T13:38:27Z 2021-11-04T13:38:27Z 2020-01-01 2021-11-04T12:11:10Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1002/dad2.12052 Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020, vol. 12, num. 1 https://doi.org/10.1002/dad2.12052 cc by-nc-nd (c) Pegueroles, Jordi et al, 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Wiley Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))