2026-04-17T12:14:37Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1810542025-12-05T12:13:16Zcom_2072_1057col_2072_478916col_2072_478917
RECERCAT
author
Pegueroles, Jordi
author
Pané, Adriana
author
Vilaplana, Eduard
author
Montal, Victor
author
Bejanin, Alexandre
author
Videla, Laura
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Carmona Iragui, María
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Barroeta, Isabel
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Ibarzabal, Ainitze
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Casajoana, Anna
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Alcolea, Daniel
author
Valldeneu, Silvia
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Altuna, Miren
author
Hollanda Ramírez, Ana M. de
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Vidal i Cortada, Josep
author
Ortega Martínez de Victoria, Emilio
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Osorio, Ricardo
author
Convit, Antonio
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Blesa González, Rafael
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Lleó Bisa, Alberto
author
Fortea Ormaechea, Juan
author
Jiménez Pineda, Amanda
author
Alzheimer's Disease Neuroimaging Initiative
2021-11-04T13:38:27Z2021-11-04T13:38:27Z2020-01-012021-11-04T12:11:10Z
Aims/hypothesis: Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. Methods: We selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (Aβ)1-42, p-tau, and t-tau levels. We performed regression analyses between these biomarkers and body mass index (BMI). Results: We included 201 individuals (mean age 73.5 years, mean BMI 27.4 kg/m2). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. Conclusions/interpretation: In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.
cc by-nc-nd (c) Pegueroles, Jordi et al, 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess
Obesitat
Demència
Obesity
Dementia
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion