2026-04-13T13:42:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1810182025-12-05T12:21:24Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Butt, Julia author Jenab, Mazda author Werner, Jill author Fedirko, Veronika author Weiderpass, Elisabete author Dahm, Christina C. author Tjønneland, Anne author Olsen, Anja author Boutron-Ruault, Marie-Christine author Rothwell, Joseph A. author Severi, Gianluca author Kaaks, Rudolf author Turzanski-Fortner, Renée author Aleksandrova, Krasimira author Schulze, Matthias B. author Palli, Domenico author Pala, Valeria author Panico, Salvatore author Tumino, Rosario author Sacerdote, Carlotta author Bueno de Mesquita, H. Bas author Van Gils, Carla H. author Gram, Inger Torhild author Lukic, Marko author Sala Serra, Núria author Sánchez Pérez, María José author Ardanaz, Eva author Chirlaque, María Dolores author Palmquist, Richard author Löwenmark, Thyra author Travis, Ruth C. author Heath, Alicia K. author Cross, Amanda J. author Freisling, Heinz author Zouiouich, Semi author Aglago, Elom K. author Waterboer, Tim author Hughes, David J. author 2021-11-04T13:58:33Z 2021-11-04T13:58:33Z 2021-01-01 2021-11-04T11:02:55Z Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse. We therefore assessed the association of serological markers of E. coli and ETBF exposure with odds of developing CRC in the European Prospective Investigation into Nutrition and Cancer (EPIC) study.Serum samples of incident CRC cases and matched controls (n = 442 pairs) were analyzed for immunoglobulin (Ig) A and G antibody responses to seven E. coli proteins and two isoforms of the ETBF toxin via multiplex serology. Multivariable-adjusted conditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of sero-positivity to E. coli and ETBF with CRC.The IgA-positivity of any of the tested E. coli antigens was associated with higher odds of developing CRC (OR: 1.42; 95% CI: 1.05-1.91). Dual-positivity for both IgA and IgG to E. coli and ETBF was associated with >1.7-fold higher odds of developing CRC, with a significant association only for IgG (OR: 1.75; 95% CI: 1.04, 2.94). This association was more pronounced when restricted to the proximal colon cancers (OR: 2.62; 95% CI: 1.09, 6.29) compared to those of the distal colon (OR: 1.24; 95% CI: 0.51, 3.00) (pheterogeneity = 0.095). Sero-positivity to E. coli and ETBF was associated with CRC development, suggesting that co-infection of these bacterial species may contribute to colorectal carcinogenesis. These findings warrant further exploration in larger prospective studies and within different population groups. Escheríchia coli Bacils Càncer colorectal Escherichia coli Bacillus (Bacteria) Colorectal cancer Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort