2026-04-17T08:05:59Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1805052025-12-05T12:35:18Zcom_2072_1057col_2072_478916col_2072_478917
RECERCAT author Blanco Palmero, Víctor Antonio author Rubio Fernández, Marcos author Antequera, Desiree author Villarejo Galende, Alberto author Molina, José Antonio author Ferrer, Isidro author Bartolome, Fernando author Carro, Eva 2021-10-11T11:06:48Z2021-10-11T11:06:48Z2021-08-272021-10-07T08:01:09Z Neuroinflammation is a common feature in Alzheimer's (AD) and Parkinson's (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here, we tried to clarify the pattern of two of the most promising biomarkers of neuroinflammation in cerebrospinal fluid (CSF) in AD and PD. This study included cognitively unimpaired elderly patients, patients with mild cognitive impairment, patients with AD dementia, and patients with PD. CSF samples were analyzed for YKL-40 and C-reactive protein (CRP). We found that CSF YKL-40 levels were significantly increased only in dementia stages of AD. Additionally, increased YKL-40 levels were found in the cerebral orbitofrontal cortex from AD patients in agreement with augmented astrogliosis. Our study confirms that these biomarkers of neuroinflammation are differently detected in CSF from AD and PD patients. cc by (c) Blanco Palmero, Víctor Antonio et al, 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Malaltia d'Alzheimer Malaltia de Parkinson Glicoproteïnes Alzheimer's disease Parkinson's disease Glycoproteins Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion