2026-04-14T07:35:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1805052025-12-05T12:35:18Zcom_2072_1057col_2072_478916col_2072_478917

urn:hdl:2445/180505 Increased YKL-40 but Not C-Reactive Protein Levels in Patients with Alzheimer’s Disease Blanco Palmero, Víctor Antonio Rubio Fernández, Marcos Antequera, Desiree Villarejo Galende, Alberto Molina, José Antonio Ferrer, Isidro Bartolome, Fernando Carro, Eva Malaltia d'Alzheimer Malaltia de Parkinson Glicoproteïnes Alzheimer's disease Parkinson's disease Glycoproteins Neuroinflammation is a common feature in Alzheimer's (AD) and Parkinson's (PD) disease. In the last few decades, a testable hypothesis was proposed that protein-unfolding events might occur due to neuroinflammatory cascades involving alterations in the crosstalk between glial cells and neurons. Here, we tried to clarify the pattern of two of the most promising biomarkers of neuroinflammation in cerebrospinal fluid (CSF) in AD and PD. This study included cognitively unimpaired elderly patients, patients with mild cognitive impairment, patients with AD dementia, and patients with PD. CSF samples were analyzed for YKL-40 and C-reactive protein (CRP). We found that CSF YKL-40 levels were significantly increased only in dementia stages of AD. Additionally, increased YKL-40 levels were found in the cerebral orbitofrontal cortex from AD patients in agreement with augmented astrogliosis. Our study confirms that these biomarkers of neuroinflammation are differently detected in CSF from AD and PD patients. 2021-10-11T11:06:48Z 2021-10-11T11:06:48Z 2021-08-27 2021-10-07T08:01:09Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/biomedicines9091094 Biomedicines, 2021, vol. 9, num. 9, p. 1094 https://doi.org/10.3390/biomedicines9091094 cc by (c) Blanco Palmero, Víctor Antonio et al, 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess MDPI AG Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))