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A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars Terrazas Martínez, Montserrat Aviñó Andrés, Anna Siddiqui, Maqbool A. Marquez, Victor E. Eritja i Casadellà, Ramon RNA Nucleòsids Estructura molecular RNA Nucleosides Molecular structure An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA. 2021-08-31T10:31:28Z 2021-08-31T10:31:28Z 2011-05-09 2021-08-31T10:31:28Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: https://doi.org/10.1021/ol200909j Organic Letters, 2011, vol. 13, num. 11, p. 2888-2891 https://doi.org/10.1021/ol200909j (c) American Chemical Society , 2011 info:eu-repo/semantics/openAccess American Chemical Society Articles publicats en revistes (Química Inorgànica i Orgànica)