2026-04-17T20:23:11Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1797832025-12-04T19:33:13Zcom_2072_1057col_2072_478908col_2072_478917col_2072_478933
RECERCAT
author
Terrazas Martínez, Montserrat
author
Aviñó Andrés, Anna
author
Siddiqui, Maqbool A.
author
Marquez, Victor E.
author
Eritja i Casadellà, Ramon
2021-08-31T10:31:28Z2021-08-31T10:31:28Z2011-05-092021-08-31T10:31:28Z
An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.
(c) American Chemical Society , 2011 info:eu-repo/semantics/openAccess
RNA
Nucleòsids
Estructura molecular
RNA
Nucleosides
Molecular structure
A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion