2026-04-18T04:32:28Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1793032025-12-05T09:23:57Zcom_2072_1057col_2072_478799col_2072_478917

00925njm 22002777a 4500 dc Fraga, Mario F. author Ballestar Tarín, Esteban author Paz, Maria F. author Ropero, Santiago author Setién, Fernando author Ballester Palacios, M. L. (Maria Lluïsa) author Heine Suñer, Damià author Cigudosa, Juan Cruz author Urioste, Miguel author Benitez, Javier author Boix-Chornet, Manuel author Sánchez-Aguilera, Abel author Ling, Charlotte author Carlsson, Emma author Poulsen, Pernille author Vaag, Allan author Stephan, Zarko author Spector, Tim D. author Wu, Yue-Zhong author Plass, Christoph author Esteller, Manel author 2021-07-22T11:44:33Z 2021-07-22T11:44:33Z 2005-07-26 2021-07-22T11:44:33Z Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. ADN Expressió gènica Histones Fenotip Bessons DNA Gene expression Histones Phenotype Twins Epigenetic differences arise during the lifetime of monozygotic twins