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urn:hdl:2445/179303 Epigenetic differences arise during the lifetime of monozygotic twins Fraga, Mario F. Ballestar Tarín, Esteban Paz, Maria F. Ropero, Santiago Setién, Fernando Ballester Palacios, M. L. (Maria Lluïsa) Heine Suñer, Damià Cigudosa, Juan Cruz Urioste, Miguel Benitez, Javier Boix-Chornet, Manuel Sánchez-Aguilera, Abel Ling, Charlotte Carlsson, Emma Poulsen, Pernille Vaag, Allan Stephan, Zarko Spector, Tim D. Wu, Yue-Zhong Plass, Christoph Esteller, Manel ADN Expressió gènica Histones Fenotip Bessons DNA Gene expression Histones Phenotype Twins Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype. 2021-07-22T11:44:33Z 2021-07-22T11:44:33Z 2005-07-26 2021-07-22T11:44:33Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1073/pnas.0500398102 Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2005, vol. 102, num. 30, p. 10604-10609 https://doi.org/10.1073/pnas.0500398102 (c) National Academy of Sciences, 2005 info:eu-repo/semantics/openAccess National Academy of Sciences Articles publicats en revistes (Ciències Fisiològiques)