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Sleep duration and napping in relation to colorectal and gastric cancer in the MCC-Spain study Papantoniou, Kyriaki Castaño-Vinyals, Gemma Espinosa, Ana Turner, Michelle C. Martín Sánchez, Vicente Casabonne, Delphine Aragonès Sanz, Núria Gómez Acebo, Inés Ardanaz, Eva Jimenez Moleon, Jose Juan Amiano, Pilar Molina Barceló, Ana Alguacil, Juan Fernández Tardón, Guillermo Huerta, José María Hernández Segura, Natalia Pérez Gómez, Beatriz Llorca, Javier Vidán Alli, Juana Olmedo Requena, Rocío Gil, Leire Castañon López, Carmen Pollan, Marina Kogevinas, Manolis Moreno Aguado, Víctor Càncer gastrointestinal Factors de risc en les malalties Son Cáncer gastrointestinal Colorectal cancer Risk factors in diseases Sleep Gastrointestinal cancer Sleep duration is a novel and potentially modifiable risk factor for cancer. We evaluated the association of self-reported sleep duration and daytime napping with odds of colorectal and gastric cancer. We included 2008 incident colorectal cancer cases, 542 gastric cancer cases and 3622 frequency-matched population controls, recruited in the MCC-Spain case-control study (2008-2013). Sleep information, socio-demographic and lifestyle characteristics were obtained through personal interviews. Multivariable adjusted logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (CI) for cancer, across categories of sleep duration (≤ 5, 6, 7, 8, ≥ 9 hours/day), daytime napping frequency (naps/week) and duration (minutes/nap). Compared to 7 hours of sleep, long sleep was associated with increased odds of colorectal (OR≥9 hours: 1.59; 95%CI 1.30-1.94) and gastric cancer (OR≥9 hours: 1.95; 1.37-2.76); short sleep was associated with increased odds of gastric cancer (OR≤5 hours: 1.32; 0.93-1.88). Frequent and long daytime naps increased the odds of colorectal (OR6-7 naps/week, ≥30 min: 1.32; 1.14-1.54) and gastric cancer (OR6-7 naps/week, ≥30 min: 1.56; 1.21-2.02). Effects of short sleep and frequent long naps were stronger among participants with night shift-work history. Sleep and circadian disruption may jointly play a role in the etiology of colorectal and gastric cancer. 2021-07-19T09:02:32Z 2021-07-19T09:02:32Z 2021-06-03 2021-07-16T07:42:40Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-91275-3 Scientific Reports, 2021, vol. 11, num. 11822 https://doi.org/10.1038/s41598-021-91275-3 cc by (c) Papantoniou, Kyriaki et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Springer Science and Business Media LLC Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))