2026-04-13T00:06:09Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1789742025-12-05T10:07:56Zcom_2072_1057col_2072_478916col_2072_478917col_2072_478929

The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition Gómez Valenzuela, Fernán Escobar, Enrico Pérez Tomás, Ricardo Montecinos, Viviana P. Càncer Inflamació Fenotip Cancer Inflammation Phenotype Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we describe a new AMP family, namely the super-cationic peptide dendrimers (SCPDs). Although all members of the series exert some antibacterial activity, we propose that special attention should be given to (KLK)2KLLKLL-NH2 (G1KLK-L2KL2), which shows selectivity for Gram-negative bacteria and virtually no cytotoxicity in HepG2 and HEK293. These results reinforce the validity of the SCPD family as a valuable class of AMP and support G1KLK-L2KL2 as a strong lead candidate for the future development of an antibacterial agent against Gram-negative bacteria. 2021-07-12T09:54:48Z 2021-07-12T09:54:48Z 2021-06-10 2021-07-09T08:27:28Z info:eu-repo/semantics/article Reproducció del document publicat a: https://doi.org/10.3389/fonc.2021.686792 Frontiers in Oncology, 2021, vol. 11, num. 686792 https://doi.org/10.3389/fonc.2021.686792 cc by (c) Gómez Valenzuela, Fernán et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Frontiers Media SA Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))