2026-04-17T01:24:11Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1782102026-03-13T18:19:24Zcom_2072_1057col_2072_478798col_2072_478858col_2072_478916col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Bonnín Roig, Caterina del Mar author Reinares, María author Martínez-Arán, Anabel, 1971- author Balanzá-Martínez, Vicent author Solé Cabezuelo, Brisa author Torrent Font, Carla author Tabarés-Seisdedos, Rafael author García-Portilla González, María Paz, 1962- author Ibáñez Cuadrado, Ángela author Amann, Benedikt L. author Arango, Celso author Ayuso Mateos, José Luis author Crespo, J. M. (José Manuel) author González-Pinto, Ana author Colom, Francesc, 1971- author Vieta i Pascual, Eduard, 1963- author Menchón Magriñá, José Manuel author Salamero, Manel author CIBERSAM Functional Remediation Group author 2021-06-10T15:04:39Z 2021-06-10T15:04:39Z 2016-01-01 2021-06-10T15:04:39Z Background: functional remediation is a novel intervention with demonstrated efficacy at improving functional outcome in euthymic bipolar patients. However, in a previous trial no significant changes in neurocognitive measures were detected. The objective of the present analysis was to test the efficacy of this therapy in the enhancement of neuropsychological functions in a subgroup of neurocognitively impaired bipolar patients. Method: a total of 188 out of 239 DSM-IV euthymic bipolar patients performing below two standard deviations from the mean of normative data in any neurocognitive test were included in this subanalysis. Repeated-measures analyses of variance were conducted to assess the impact of the treatment arms [functional remediation, psychoeducation, or treatment as usual (TAU)] on participants' neurocognitive and functional outcomes in the subgroup of neurocognitively impaired patients. Results: patients receiving functional remediation (n = 56) showed an improvement on delayed free recall when compared with the TAU (n = 63) and psychoeducation (n = 69) groups as shown by the group × time interaction at 6-month follow-up [F 2,158 = 3.37, degrees of freedom (df) = 2, p = 0.037]. However, Tukey post-hoc analyses revealed that functional remediation was only superior when compared with TAU (p = 0.04), but not with psychoeducation (p = 0.10). Finally, the patients in the functional remediation group also benefited from the treatment in terms of functional outcome (F 2,158 = 4.26, df = 2, p = 0.016). Conclusions: functional remediation is effective at improving verbal memory and psychosocial functioning in a sample of neurocognitively impaired bipolar patients at 6-month follow-up. Neurocognitive enhancement may be one of the active ingredients of this novel intervention, and, specifically, verbal memory appears to be the most sensitive function that improves with functional remediation. Trastorn bipolar Trastorns de la cognició Rehabilitació de drogoaddictes Manic-depressive illness Cognition disorders Narcotics addicts rehabilitation Effects of functional remediation on neurocognitively impaired bipolar patients: enhancement of verbal memory