2026-04-17T03:16:37Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1780942025-12-04T20:37:49Zcom_2072_1057col_2072_478800col_2072_478917

00925njm 22002777a 4500 dc Soriano Arandes, Antoni author Caylà i Buqueras, Joan A. author Queiroga Gonçalves, Alessandra author Orcau i Palau, Àngels author Noguera Julian, Antoni author Padilla, Emma author Solà Segura, Elisabet author Ríus Gordillo, Neus author Espiau, María author García Lerín, Mónica G. author Rifà Pujol, Maria Àngels author Gómez i Prat, Jordi author Macia Rieradevall, Esperança author Martín Nalda, Andrea author Eril Rius, Maria author Santos Santiago, José author Busquets Poblet, Lídia author Morales Martínez, Raisa author Pérez-Porcuna, Tomàs M. author 2021-06-08T08:14:00Z 2021-06-08T08:14:00Z 2020-09-04 2021-06-08T08:14:00Z Introduction: Tuberculosis (TB) is a global infectious disease. In low-incidence countries, paediatric TB affects mostly immigrant children and children of immigrants. We hypothesize that these children are at risk of exposure to Mycobacterium tuberculosis when they travel to the country of origin of their parents to visit friends and relatives (VFR). In this study, we aim to estimate the incidence rate and risk factors associated to latent tuberculosis infection (LTBI) and TB in VFR children. Methods and analysis: A prospective study will be carried out in collaboration with 21 primary health care centres (PCC) and 5 hospitals in Catalonia, Spain. The study participants are children under 15 years of age, either immigrant themselves or born to immigrant parents, who travel to countries with high incidence of TB (≥ 40 cases/100,000 inhabitants). A sample size of 492 children was calculated. Participants will be recruited before traveling, either during a visit to a travel clinic or to their PCC, where a questionnaire including sociodemographic, epidemiological and clinical data will be completed, and a tuberculin skin test (TST) will be performed and read after 48 to 72 hours; patients with a positive TST at baseline will be excluded. A visit will be scheduled eight to twelve-weeks after their return to perform a TST and a QuantiFERON-TB Gold Plus test. The incidence rate of LTBI will be estimated per individual/month and person/year per country visited, and also by age-group. Tuberculosi Infeccions en els infants Tuberculosis Infection in children Tuberculosis infection in children visiting friends and relatives in countries with high incidence of tuberculosis: A study protocol