2026-04-13T02:51:48Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1778252025-12-05T13:08:15Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Seppälä, Toni T. author Dominguez Valentin, Mev author Crosbie, Emma J. author Engel, Christoph author Aretz, Stefan author Macrae, Finlay author Winship, Ingrid author Capellá, G. (Gabriel) author Thomas, Huw author Hovig, Eivind author Nielsen, Maartje author Sijmons, Rolf H. author Bertario, Lucio author Bonanni, Bernardo author Tibiletti, Maria G. author Cavestro, Giulia Martina author Mints, Miriam author Gluck, Nathan author Katz, Lior author Heinimann, Karl author Vaccaro, Carlos A. author Green, Kate author Lalloo, Fiona author Hill, James author Schmiegel, Wolff author Vangala, Deepak author Perne, Claudia author Strauß, Hans Georg author Tecklenburg, Johanna author Holinski Feder, Elke author Steinke-Lange, Verena author Mecklin, Jukka-Pekka author Plazzer, John-Paul author Pineda Riu, Marta author Navarro García, Matilde author Vida, Joan B. author Kariv, Revital author Rosner, Guy author Piñero, Tamara Alejandra author Pavicic, Walter Hernán author Kalfayan, Pablo author Ten Broeke, Sanne W. author Jenkins, Mark A. author Sunde, Lone author Bernstein, Inge author Burn, John author Greenblatt, Marc author De Vos Tot Nederveen Cappel, Wouter H. author Della Valle, Adriana author Lopez Kostner, Francisco author Alvarez Valenzuela, Karin author Büttner, Reinhard author Görgens, Heike author Morak, Monika author Holzapfel, Stefanie author Hüneburg, Robert author Von Knebel Doeberitz, Magnus author Loeffler, Markus author Redler, Silke author Weitz, Jürgen author Pylvänäinen, Kirsi author Renkonen Sinisalo, Laura author Lepistö, Anna author Hopper, John L. author Win, Aung K. author Lindor, Noralane M. author Gallinger, Steven author Le Marchand, Loïc author Newcomb, Polly A. author Figueiredo, Jane C. author Thibodeau, Stephen N. author Therkildsen, Christina author Wadt, Karin A.W. author Mourits, Marian J.E. author Ketabi, Zohreh author Denton, Oliver G. author Rødland, Einar Andreas author Vasen, Hans author Neffa, Florencia author Esperon, Patricia author Tjandra, Douglas author Möslein, Gabriela author Sampson, Julian R. author Rokkones, Erik author Evans, D. Gareth author Møller, Pål author 2021-05-31T12:39:35Z 2021-05-31T12:39:35Z 2021-03-17 2021-05-31T12:39:35Z Purpose: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. Methods: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30e69 years. Results: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. Conclusion: Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene- and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syn- drome to improve outcomes. Càncer d'ovari Càncer d'endometri Mortalitat Ovarian cancer Endometrial cancer Mortality Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report