2026-04-13T07:18:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1777112025-12-05T12:03:06Zcom_2072_1057col_2072_478916col_2072_478917

Impact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain Rodilla Sala, Enrique López Carmona, Maria Dolores Cortes, Xavi Cobos Palacios, Lidia Canales, Sergio Sáez, Maria Carmen Campos Escudero, Samara Rubio-Rivas, Manuel Díez Manglano, Jesús Freire Castro, Santiago Vázquez Piqueras, Nuria Mateo Sanchis, Elisabeth Pesqueira Fontán, Paula María Magallanes Gamboa, Jeffrey Oskar González García, Andrés Madrid Romero, Victor Tamargo Chamorro, Lara González Moraleja, Julio Villanueva Martínez, Javier González Noya, Amara Suárez Lombraña, Ana Gracia Gutiérrez, Anyuli López Reboiro, Manuel Lorenzo Ramos-Rincón, José Manuel Gómez Huelgas, Ricardo SEMI-COVID-19 Network Malalties cardiovasculars Insuficiència cardíaca COVID-19 Cardiovascular diseases Heart failure COVID-19 Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively, P<0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27, P=0.0001; ORadj: 1.48, P=0.0001, respectively) after adjusting for sex (males, ORadj: 1.6, P=0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7, P=0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6, P=0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization. 2021-05-27T09:51:31Z 2021-05-27T09:51:31Z 2021-03-03 2021-05-26T13:46:48Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1161/HYPERTENSIONAHA.120.16563 Hypertension, 2021, vol. 77, num. 3, p. 856-867 https://doi.org/10.1161/HYPERTENSIONAHA.120.16563 (c) American Heart Association, Inc., 2021 info:eu-repo/semantics/openAccess Wolters Kluwer Health Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))