2026-04-17T19:00:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1775332025-12-05T14:19:10Zcom_2072_1057col_2072_478902col_2072_478917

Optical Control of GABAA Receptors with a Fulgimide-Based Potentiator Rustler, Karin Maleeva, Galyna Gomila Juaneda, Alexandre Gorostiza Langa, Pablo Ignacio Bregestovski, Piotr König, Burkhard Fototeràpia Neurotransmissió Phototherapy Neural transmission Optogenetic and photopharmacological tools to manipulate neuronal inhibition have limited efficacy and reversibility. We report the design, synthesis, and biological evaluation of Fulgazepam, a fulgimide derivative of benzodiazepine that behaves as a pure potentiator of ionotropic γ-aminobutyric acid receptors (GABA A Rs) and displays full and reversible photoswitching in vitro and in vivo. The compound enables high-resolution studies of GABAergic neurotransmission, and phototherapies based on localized, acute, and reversible neuroinhibition. 2021-05-25T07:00:46Z 2021-05-25T07:00:46Z 2020-10-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://hdl.handle.net/2445/177533 https://doi.org/10.1002/chem.202000710 32307732 eng Reproducció del document publicat a: https://doi.org/10.1002/chem.202000710 Chemistry - A European Journal, 2020, vol. 26, num. 56, p. 12722-12727 info:eu-repo/grantAgreement/EC/H2020/945539/EU//HBP SGA3 cc by (c) Rustler et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess 6 p. application/pdf Wiley-VCH GmbH Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))