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Liquid chromatographic fingerprints for the characterization of flavanol-rich nutraceuticals based on 4-dimethylaminocinnamaldehyde precolumn derivatization Vidal Casanella, Oscar Núñez Burcio, Oscar Saurina, Javier Flavonoides Plantes medicinals Aliments funcionals Flavonoids Medicinal plants Functional foods Flavanols consist of a great family of bioactive molecules displaying a wide range of health-promoting attributes for humans, including antioxidant, antimicrobial or an-ti-inflammatory effects. As a result, botanical species rich in this type of compounds are often used to develop nutraceutical products or dietary supplements with recognized healthy attrib-utes. This paper aims at characterizing nutraceutical products using liquid chromatographic fin-gerprints related to flavanol composition. Catechins and their oligomers were exploited to characterize and authenticate of various commercial products prepared with extracts of red ber-ries and medicinal plants. These compounds resulted in interesting descriptors of some fruits and vegetables, thus providing an additional perspective for the study of nutraceuticals. For such a purpose, a new method based on liquid chromatography with UV/Vis detection (HPLC-UV/Vis) with precolumn derivatization with 4-dimethylaminocinnamaldehyde was de-veloped. Results indicated that the separation of flavanols was very complex due to the degrada-tion of procyanidin derivatives. The resulting data sets were analyzed using chemometric methods such as principal component analysis and partial least square-discriminant analysis. Despite the complexity of chromatographic fingerprints, nutraceutical samples could be dis-criminated according to their main ingredients. In general, catechin and epicatechin were the most abundant compounds in the different samples and procyanidin A2 was highly specific of cranberry. 2021-05-19T12:42:05Z 2021-05-19T12:42:05Z 2021-05-06 2021-05-19T12:42:05Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2218-0532 https://hdl.handle.net/2445/177423 712102 eng Reproducció del document publicat a: https://doi.org/10.3390/scipharm89020018 Scientia Pharmaceutica, 2021, vol. 89, num. 18 https://doi.org/10.3390/scipharm89020018 cc-by (c) Vidal-Casanella, Oscar et al., 2021 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess 13 p. application/pdf MDPI Articles publicats en revistes (Enginyeria Química i Química Analítica)