2026-04-17T14:12:55Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1773062025-12-05T09:21:12Zcom_2072_1057col_2072_478799col_2072_478917

00925njm 22002777a 4500 dc Boix-Chornet, Manuel author Fraga, Mario F. author Villar Garea, Ana author Caballero, Rosalía author Espada, Jesús author Nuñez, Antonio author Casado, Juan author Largo, Cristina author Casal, J. Ignacio author Cigudosa, Juan Cruz author Franco, Luis author Esteller, Manel author Ballestar Tarín, Esteban author 2021-05-14T14:57:57Z 2021-05-14T14:57:57Z 2006-05-12 2021-05-14T14:57:57Z Nuclear events such as chromatin condensation, DNA cleavage at internucleosomal sites, and histone release from chromatin are recognized as hallmarks of apoptosis. However, there is no complete understanding of the molecular events underlying these changes. It is likely that epigenetic changes such as DNA methylation and histone modifications that are involved in chromatin dynamics and structure are also involved in the nuclear events described. In this report we have shown that apoptosis is associated with global DNA hypomethylation and histone deacetylation events in leukemia cells. Most importantly, we have observed a particular epigenetic signature for early apoptosis defined by a release of hypoacetylated and trimethylated histone H4 and internucleosomal fragmented DNA that is hypermethylated and originates from perinuclear heterochromatin. These findings provide one of the first links between apoptotic nuclear events and epigenetic markers. Apoptosi Fisiologia Histones Metabolisme Apoptosis Physiology Histones Metabolism Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis