2026-04-18T03:02:09Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1765852025-12-04T19:31:09Zcom_2072_1057col_2072_478916col_2072_478908col_2072_478917

00925njm 22002777a 4500 dc Pérez, Raúl F. author Tejedor, Juan Ramón author Santamarina Ojeda, Pablo author López Martínez, Virginia author Urdinguio, Rocío G. author Villamañán, Lucía author Candiota, Ana Paula author Vidal, Noemí author Barradas, Marta author Fernández Marcos, Pablo José author Serrano Marugán, Manuel author Fernández, Agustín F. author Fraga, Mario F. author 2021-04-26T07:10:25Z 2021-04-26T07:10:25Z 2021-01-01 2021-04-23T09:41:38Z Aging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. While many of these observations arise from the use of mouse models, there is a lack of systematic comparisons of human and mouse epigenetic patterns in the context of disease. However, such comparisons are significant as they allow to establish the extent to which some of the observed similarities or differences arise from pre-existing species-specific epigenetic traits. Here, we have used reduced representation bisulfite sequencing to profile the brain methylomes of young and old, tumoral and non-tumoral brain samples from human and mouse. We first characterized the baseline epigenomic patterns of the species and subsequently focused on the DNA methylation alterations associated with cancer and aging. Next, we described the functional genomic and epigenomic context associated with the alterations, and finally we integrated our data to study interspecies DNA methylation levels at orthologous CpG sites. Globally, we found considerable differences between the characteristics of DNA methylation alterations in cancer and aging in both species. Moreover, we describe robust evidence for the conservation of the specific cancer and aging epigenomic signatures in human and mouse. Our observations point towards the preservation of the functional consequences of these alterations at multiple levels of genomic regulation. Finally, our analyses reveal a role for the genomic context in explaining disease- and species-specific epigenetic traits.© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. Càncer Envelliment Epigenètica Cancer Aging Epigenetics Conservation of aging and cancer epigenetic signatures across human and mouse