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Epigenetics in Cancer Esteller, Manel ADN Epigènesi Expressió gènica Proteïnes supressores de tumors Fisiologia DNA Epigenesis Gene expression Tumor suppressor protein Physiology Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name "the causal interactions between genes and their products, which bring the phenotype into being," epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence. 2021-04-15T10:35:56Z 2021-04-15T10:35:56Z 2008-03-13 2021-04-15T10:35:57Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1056/NEJMra072067 New England Journal of Medicine, 2008, vol. 358, num. 11, p. 1148-1159 https://doi.org/10.1056/NEJMra072067 (c) Massachusetts Medical Society, 2008 info:eu-repo/semantics/openAccess Massachusetts Medical Society Articles publicats en revistes (Ciències Fisiològiques)