2026-04-18T05:53:32Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1760752025-12-05T14:11:08Zcom_2072_1057col_2072_478815col_2072_478917

00925njm 22002777a 4500 dc Palmas, Lucia author Aroffu, Matteo author Petretto, Giacomo L. author Escribano Ferrer, Elvira author Díez Sales, Octavio author Usach, Iris author Peris, José Esteban author Marongiu, Francesca author Ghavam, Mansureh author Fais, Sara author Orrù, Germano author Rached, Rita Abi author Manca, Maria Letizia author Manconi, Maria author 2021-04-08T11:37:13Z 2021-04-08T11:37:13Z 2020-08-28 2021-04-08T11:37:13Z This work aimed at developing a mouthwash based on liposomes loading Citrus limon var. pompia essential oil or citral to treat oropharyngeal diseases. Vesicles were prepared by dispersing phosphatidylcholine and pompia essential oil or citral at increasing amounts (12, 25 and 50 mg/mL) in water. Transparent vesicle dispersions were obtained by direct sonication avoiding the use of organic solvents. Cryogenic transmission electron microscopy (cryo-TEM) confirmed the formation of unilamellar, spherical and regularly shaped vesicles. Essential oil and citral loaded liposomes were small in size (~110 and ~100 nm, respectively) and negatively charged. Liposomes, especially those loading citral, were highly stable as their physico-chemical properties did not change during storage. The formulations were highly biocompatible against keratinocytes, were able to counteract the damages induced in cells by using hydrogen peroxide, and able to increase the rate of skin repair. In addition, liposomes loading citral at higher concentrations inhibited the proliferation of cariogenic bacterium Olis essencials Llimones Malalties de la boca Estreptococs Essences and essential oils Lemons Mouth diseases Streptococcus Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases