2026-04-13T13:15:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1757992025-12-05T12:08:32Zcom_2072_1057col_2072_478916col_2072_478917

Oral Anticoagulant Adequacy in Non-Valvular Atrial Fibrillation in Primary Care: A Cross-Sectional Study Using Real-World Data (Fantas-TIC Study) Dalmau Llorca, Maria Rosa Aguilar Martín, Carina Carrasco Querol, Noèlia Hernández Rojas, Zojaina Forcadell Drago, Emma Rodríguez Cumplido, Dolores Pepió i Vilaubí, Josep M. Castro Blanco, Elisabet Gonçalves, Alessandra Queiroga Fernández Sáez, José Fibril·lació auricular Anticoagulants (Medicina) Atrial fibrillation Anticoagulants (Medicine) Background: Oral anticoagulants (OAs) are the treatment to prevent stroke in atrial fibrillation (AF). Anticoagulant treatment choice in non-valvular atrial fibrillation (NVAF) must be individualized, taking current guidelines into account. Adequacy of anticoagulant therapy under the current criteria for NVAF in real-world primary care is presented. Methods: Cross-sectional study, with real-world data from patients treated in primary care (PC). Data were obtained from the System for the Improvement of Research in Primary Care (SIDIAP) database, covering 60,978 NVAF-anticoagulated patients from 287 PC centers in 2018. Results: In total, 41,430 (68%) were treated with vitamin K antagonists (VKAs) and 19,548 (32%) NVAF with direct-acting oral anticoagulants (DOACs). Inadequate prescription was estimated to be 36.0% and 67.6%, respectively. Most DOAC inadequacy (77.3%) was due to it being prescribed as a first-line anticoagulant when there was no history of thromboembolic events or intracranial hemorrhage (ICH). A total of 22.1% had missing estimated glomerular filtration rate (eGFR) values. Common causes of inadequate VKA prescription were poor control of time in therapeutic range (TTR) (98.8%) and ICH (2.2%). Conclusions: Poor adequacy to current criteria was observed, being inadequacy higher in DOACs than in VKAs. TTR and GFR should be routinely calculated in electronic health records (EHR) to facilitate decision-making and patient safety. 2021-03-26T09:55:01Z 2021-03-26T09:55:01Z 2021-02-24 2021-03-25T13:17:59Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/ijerph18052244 International Journal of Environmental Research and Public Health, 2021, vol. 18, num. 5 https://doi.org/10.3390/ijerph18052244 cc by (c) Dalmau Llorca et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))