2026-04-14T03:37:50Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1756882025-11-19T10:43:19Zcom_2072_1057col_2072_478906col_2072_478917col_2072_478931

00925njm 22002777a 4500 dc Castells Sánchez, Alba author Roig-Coll, Francesca author Lamonja-Vicente, Noemí author Altés Magret, Marina author Torán Monserrat, Pere author Via i García, Marc author García Molina, Alberto author Tormos, José María author Heras, Antonio author Alzamora, María Teresa author Forés, Rosa author Pera, Guillem author Dacosta-Aguayo, Rosalia author Soriano Raya, Juan José author Cáceres, Cynthia author Montero Alía, Pilar author Montero Alia, Juan José author Jiménez González, María Mercedes author Hernández Pérez, María author Perera Lluna, Alexandre author Grove, George A. author Munuera, Josep author Domènech, Sira author Erickson, Kirk I. author Mataró Serrat, Maria author 2021-03-24T15:35:51Z 2021-03-24T15:35:51Z 2019-08-14 2021-03-24T15:35:51Z Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses. Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (CCT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention. Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample. Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03123900. Persones grans Exercici Neurociència cognitiva Older people Exercise Cognitive neuroscience Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol