2026-04-17T05:54:24Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1754232025-12-04T19:25:45Zcom_2072_1057col_2072_478858col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Gómez Junyent, Joan author Lora-Tamayo Morillo-Velarde, Jaime author Baraia Etxaburu, Josu author Sánchez Somolinos, Mar author Iribarren, José A. author Rodriguez Pardo, Dolors author Praena Segovia, Julia author Sorlí, Luisa author Bahamonde, Alberto author Riera, Melchor author Rico, Alicia author Toro, Maria Dolores del author Morata, Laura author Cobo Reinoso, Javier author Falgueras, Luis author Benito Hernández, M. Natividad de author Muñez Rubio, Elena author Jover Sáenz, Alfredo author Pigrau, Carles author Ariza Cardenal, Javier author Murillo Rubio, Óscar author GEIO-SEIMC (Bone and Joint Infection Study Group of the Spanish Society of Infectious Diseases and Clinical Microbiology) author REIPI (Spanish Network for Research in Infectious Diseases) author 2021-03-19T11:47:27Z 2021-03-19T11:47:27Z 2021-01-26 2021-03-19T08:05:09Z Objectives: To compare the characteristics and outcomes of cases with acute prosthetic joint infection (PJI; early post-surgical or hematogenous) by Staphylococcus aureus managed with implant removal (IRm) or debridement and retention (DAIR). To analyze the outcomes of all cases managed with IRm (initially or after DAIR failure). Methods: Retrospective, multicenter, cohort study of PJI by S. aureus (2003-2010). Overall failure included mortality within 60 days since surgery and local failure due to staphylococcal persistence/relapse. Results: 499 cases, 338 initially managed with DAIR, 161 with IRm. Mortality was higher in acute PJI managed initially with IRm compared to DAIR, but not associated with the surgical procedure, after propensity score matching. Underlying conditions, hemiarthroplasty, and methicillin-resistant S. aureus were risk factors for mortality. Finally, 249 cases underwent IRm (88 after DAIR failure); overall failure was 15.6%. Local failure (9.3%) was slightly higher in cases with several comorbidities, but independent of previous DAIR, type of IRm, and rifampin treatment. Conclusions: In a large multicenter study of S. aureus PJI managed with IRm, failure was low, but mortality significant, especially in cases with acute PJI and underlying conditions, but not associated with the IRm itself. Rifampin efficacy was limited in this setting. Infeccions per estafilococs Pròtesis Infeccions quirúrgiques Staphylococcal infections Prosthesis Surgical wound infection Implant Removal in the Management of Prosthetic Joint Infection by Staphylococcus aureus: Outcome and Predictors of Failure in a Large Retrospective Multicenter Study