2026-04-17T06:05:51Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1753172025-12-04T21:15:48Zcom_2072_1057col_2072_478781col_2072_478917
RECERCAT author Tarragó-Celada, Josep author Foguet Coll, Carles author Tarrado Castellarnau, Míriam Neus author Marín Martínez, Silvia author Hernández-Alias, Xavier author Perarnau, Jordi author Morrish, Fionnuala author Hockenbery, David author Gomis i Cabré, Roger author Ruppin, Eytan author Yuneva, Mariia author Atauri Carulla, Ramón de author Cascante i Serratosa, Marta 2021-03-18T12:33:58Z2021-03-18T12:33:58Z2021-01-232021-03-18T12:33:58Z With most cancer-related deaths resulting from metastasis, the development of new therapeutic approaches against metastatic colorectal cancer (mCRC) is essential to increasing patient survival. The metabolic adaptations that support mCRC remain undefined and their elucidation is crucial to identify potential therapeutic targets. Here, we employed a strategy for the rational identification of targetable metabolic vulnerabilities. This strategy involved first a thorough metabolic characterisation of same-patient-derived cell lines from primary colon adenocarcinoma (SW480), its lymph node metastasis (SW620) and a liver metastatic derivative (SW620-LiM2), and second, using a novel multi-omics integration workflow, identification of metabolic vulnerabilities specific to the metastatic cell lines. We discovered that the metastatic cell lines are selectively vulnerable to the inhibition of cystine import and folate metabolism, two key pathways in redox homeostasis. Specifically, we identified the system xCT and MTHFD1 genes as potential therapeutic targets, both individually and combined, for combating mCRC. cc-by (c) Tarragó-Celada, Josep et al., 2021 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess Càncer colorectal Metàstasi Metabolisme Colorectal cancer Metastasis Metabolism Cysteine and Folate metabolism are targetable vulnerabilities of metastatic colorectal cancer info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion