2026-04-17T02:40:43Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1752332025-12-05T14:10:13Zcom_2072_1057col_2072_478815col_2072_478917

00925njm 22002777a 4500 dc Suñé i Negre, Josep M. (Josep Maria) author García Montoya, Encarna author Pérez Lozano, Pilar author Aguilar Díaz, Johnny E. author Roig Carreras, Manel author Fuster García, Roser author Miñarro Carmona, Montserrat author Ticó Grau, Josep R. author 2021-03-17T12:19:28Z 2021-03-17T12:19:28Z 2011-10-10 The SeDeM expert system is a methodology which is applied in preformulation and formulation studies of medicines specifically in solid dosage forms. This system informs on the physical profile of powdered substances (APIs and excipients) used to formulate drugs (Suñé et al, 2005; García et al, 2010; Aguilar et al, 2009). By determining whether powders (API or excipient) are suitable for direct compression, the SeDeM profile will inform about the advantages and gaps of those powdered substance to be used in direct compression, so the system informs on whether the direct compression method is appropriate (e.g.. wet granulation should be applied before compression). The characterization of powdered substances by SeDeM facilitates the identification of the characteristics that require amendment in order to obtain tablets by direct compression. This system thus provides information that will ensure the robust design of the formulation in the final product. This new method is based on the selection and application of several parameters that the formulation must fulfill to ensure a successful tablet elaborated by direct compression... Sistemes experts Medicaments Expert systems Drugs SeDeM Diagram: A New Expert System for the Formulation of Drugs in Solid Form