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urn:hdl:2445/175233 SeDeM Diagram: A New Expert System for the Formulation of Drugs in Solid Form Suñé i Negre, Josep M. (Josep Maria) García Montoya, Encarna Pérez Lozano, Pilar Aguilar Díaz, Johnny E. Roig Carreras, Manel Fuster García, Roser Miñarro Carmona, Montserrat Ticó Grau, Josep R. Sistemes experts Medicaments Expert systems Drugs The SeDeM expert system is a methodology which is applied in preformulation and formulation studies of medicines specifically in solid dosage forms. This system informs on the physical profile of powdered substances (APIs and excipients) used to formulate drugs (Suñé et al, 2005; García et al, 2010; Aguilar et al, 2009). By determining whether powders (API or excipient) are suitable for direct compression, the SeDeM profile will inform about the advantages and gaps of those powdered substance to be used in direct compression, so the system informs on whether the direct compression method is appropriate (e.g.. wet granulation should be applied before compression). The characterization of powdered substances by SeDeM facilitates the identification of the characteristics that require amendment in order to obtain tablets by direct compression. This system thus provides information that will ensure the robust design of the formulation in the final product. This new method is based on the selection and application of several parameters that the formulation must fulfill to ensure a successful tablet elaborated by direct compression... 2021-03-17T12:19:28Z 2021-03-17T12:19:28Z 2011-10-10 info:eu-repo/semantics/bookPart info:eu-repo/semantics/publishedVersion Reprodució del document publicat a: http://doi.org/10.5772/16540 Chapter 2 in: Vizureanu, Petrică. 2011. Expert Systems for Human, Materials and Automation. IntechOpen. ISBN: 978-953-51-5537-9. DOI: 10.5772/700. pp: 17-34 http://doi.org/10.5772/16540 cc by (c) Suñé i Negre, Josep M. et al., 2011 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess IntechOpen Llibres / Capítols de llibre (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)