2026-04-13T18:27:53Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1742932025-12-05T09:34:22Zcom_2072_1057col_2072_478798col_2072_478799col_2072_478916col_2072_478917
RECERCAT author Koelsche, Christian author Schrimpf, Daniel author Stichel, Damian author Sill, Martin author Sahm, Felix author Reuss, David E. author Blattner, Mirjam author Worst, Barbara author Heilig, Christoph E. author Beck, Katja author Horak, Peter author Mautner, Victor-Felix author Schittenhelm, Jens author Serrano, Jonathan author Snuderl, Matija author Büttner, Reinhard author Klingebiel, Thomas author Buslei, Rolf author Gessler, Manfred author Wesseling, Pieter author Brandner, Sebastian author Jaunmuktane, Zane author Dinjens, Winand N. M. author Lyskjær, Iben author Schirmacher, Peter author Stenzinger, Albrecht author Brors, Benedikt author Glimm, Hanno author Heining, Christoph author Tirado, Oscar M. author Sáinz Jaspeado, Miguel Guillermo author Alonso, Javier author García del Muro Solans, Xavier author Mora Salvador, Jaume author Moran, Sebastian author Esteller, Manel author Benhamida, Jamal K. author Ladanyi, Marc author Wardelmann, Eva author Antonescu, Cristina author Flanagan, Adrienne author Dirksen, Uta author Baumhoer, Daniel author Hartmann, Wolfgang author Hohenberger, Peter author Vokuhl, Christian author Flucke, Uta author Petersen, Iver author Mechtersheimer, Gunhild author Capper, David author Jones, David T. W. author Fröhling, Stefan author Pfister, Stefan M. author Kreutzfeldt, Simon author Paff, Elke author von Deimling, Andreas author Stark, Sebastian author Johann, Pascal author Selt, Florian author Ecker, Jonas author Sturm, Dominik author Pajtler, Kristian W. author Reinhardt, Annekathrin author Wefers, Annika K. author Sievers, Philipp author Suwala, Abigail author Ebrahimi, Azadeh author Fernández Klett, Francisco author Casalini, Belén author Korshunov, Andrey author Hovestadt, Volker author Kommoss, Felix K. F. author Kriegsmann, Mark author Schick, Matthias author Bewerunge-Hudler, Melanie author Milde, Till author Kulozik, Andreas E. author Witt, Olaf author Kool, Marcel author Romero-pérez, Laura author Grünewald, Thomas G. P. author Kirchner, Thomas author Wick, Wolfgang author Platten, Michael author Unterberg, Andreas author Uhl, Matthias author Abdollahi, Amir author Lehner, Burkhard author Debus, Jürgen author Thomas, Christian author Hasselblatt, Martin author Paulus, Werner author Hartmann, Christian author Staszewski, Ori author Prinz, Marco author Hench, Jürgen author Frank, Stephan author Versleijen-Jonkers, Yvonne M. H. author Mentzel, Thomas author Weidema, Marije E. author Griewank, Klaus author Álava, Enrique de author Martín, Juan Díaz author Idoate Gastearena, Miguel A. author Chang, Kenneth Tou-En author Low, Sharon Yin Yee author Cuevas-Bourdier, Adrian author Mittelbronn, Michel author Mynarek, Martin author Schüller, Ulrich author Rutkowski, Stefan 2021-02-25T10:00:03Z2021-02-25T10:00:03Z2021-01-212021-02-25T09:38:31Z Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications. cc by (c) Koelsche et al., 2021 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Sarcoma ADN Sarcoma DNA Sarcoma classification by DNA methylation profiling info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion