2026-04-13T05:55:37Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1742742025-12-05T16:26:16Zcom_2072_1057col_2072_478917col_2072_478921
RECERCAT
author
Puig Butillé, Joan Anton
author
Malvehy, J. (Josep)
author
Potrony Mateu, Míriam
author
Trullas, Carles
author
García García, Francisco
author
Dopazo, Joaquín
author
Puig i Sardà, Susana
2021-02-24T16:36:10Z2021-02-24T16:36:10Z2013-05-232021-02-24T16:36:10Z
Cutaneous field of cancerization (CFC) is caused in part by the carcinogenic effect of the cyclobutane pyrimidine dimers CPD and 6‐4 photoproducts (6‐4PPs). Photoreactivation is carried out by photolyases which specifically recognize and repair both photoproducts. The study evaluates the molecular effects of topical application of a film‐forming medical device containing photolyase and UV filters on the precancerous field in AK from seven patients. Skin improvement after treatment was confirmed in all patients by histopathological and molecular assessment. A gene set analysis showed that skin recovery was associated with biological processes involved in tissue homoeostasis and cell maintenance. The CFC response was associated with over‐expression of the CPI‐17 gene, and a dependence on the initial expression level was observed (P = 0.001). Low CPI‐17 levels were directly associated with pro‐inflammatory genes such as TNF (P = 0.012) and IL‐1B (P = 0.07). Our results suggest a role for CPI‐17 in restoring skin homoeostasis in CFC lesions.
(c) cc-by, Puig Butillé, et. al., 2013 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
Càncer de pell
Histopatologia
Homeòstasi
Skin cancer
Pathological histology
Homeostasis
Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/publishedVersion