2026-04-14T03:14:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1742742025-12-05T16:26:16Zcom_2072_1057col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Puig Butillé, Joan Anton author Malvehy, J. (Josep) author Potrony Mateu, Míriam author Trullas, Carles author García García, Francisco author Dopazo, Joaquín author Puig i Sardà, Susana author 2021-02-24T16:36:10Z 2021-02-24T16:36:10Z 2013-05-23 2021-02-24T16:36:10Z Cutaneous field of cancerization (CFC) is caused in part by the carcinogenic effect of the cyclobutane pyrimidine dimers CPD and 6‐4 photoproducts (6‐4PPs). Photoreactivation is carried out by photolyases which specifically recognize and repair both photoproducts. The study evaluates the molecular effects of topical application of a film‐forming medical device containing photolyase and UV filters on the precancerous field in AK from seven patients. Skin improvement after treatment was confirmed in all patients by histopathological and molecular assessment. A gene set analysis showed that skin recovery was associated with biological processes involved in tissue homoeostasis and cell maintenance. The CFC response was associated with over‐expression of the CPI‐17 gene, and a dependence on the initial expression level was observed (P = 0.001). Low CPI‐17 levels were directly associated with pro‐inflammatory genes such as TNF (P = 0.012) and IL‐1B (P = 0.07). Our results suggest a role for CPI‐17 in restoring skin homoeostasis in CFC lesions. Càncer de pell Histopatologia Homeòstasi Skin cancer Pathological histology Homeostasis Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters