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ERBB2mRNA expression and response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-positive breast cancer Griguolo, Gaia Brasó Maristany, Fara González Farré, Blanca Pascual, Tomás Chic Ruché, Núria Saurí, Tamara Kates, Ronald Gluz, Oleg Martínez, Débora Paré, Laia Tsvetkova, Vassilena Pesantez, David Vidal Losada, Maria Jesús Adamo, Barbara Muñoz Mateu, Montserrat Galván, Patricia Barberá, Laura Cuatrecasas Freixas, Miriam Christgen, Mathias Kreipe, Hans Monge Escartín, Inés Villagrasa, Patricia Soy Muner, Dolors Giarratano, Tommaso Dieci, Maria Vittoria Conte, Pierfranco Harbeck, Nadia Guarneri, Valentina Prat Aparicio, Aleix Càncer de mama Receptors d'hormones Breast cancer Hormone receptors Trastuzumab emtansine (T-DM1) is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer (BC) and for residual disease after neoadjuvant therapy; however, not all patients benefit. Here, we hypothesized that the heterogeneity in the response seen in patients is partly explained by the levels of human epidermal growth factor receptor 2 gene (ERBB2) mRNA.We analyzed ERBB2 expression using a clinically applicable assay in formalin-fixed para n-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1. The association of ERBB2 levels and response was further validated in 161 baseline tumors from the West German Study (WGS) Group ADAPT phase II trial exploring neoadjuvant T-DM1 and 9 in vitro BC cell lines. Finally, 2021-02-24T16:59:37Z 2021-02-24T16:59:37Z 2020-07-14 2021-02-24T16:59:37Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.3390/cancers12071902 Cancers, 2020, vol. 12(7), num. 1902 https://doi.org/10.3390/cancers12071902 info:eu-repo/grantAgreement/EC/H2020/847912/EU//RESCUER cc-by (c) Griguolo, Gaia et al., 2020 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess MDPI Articles publicats en revistes (Medicina)