2026-04-17T01:24:38Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1742332025-11-20T15:07:20Zcom_2072_1057col_2072_478916col_2072_478917
RECERCAT author Brena, David author Bertran, Joan author Porta de la Riva, Montserrat author Guillen, Yolanda author Cornes, Eric author Kukhtar, Dmytro author Campos Vicens, Lluís author Fernández, Lierni author Pecharroman, Irene author García López, Albert author Islam, Abul B. M. M. K. author Marruecos, Laura author Bigas Salvans, Anna author Cerón Madrigal, Julián author Espinosa, Lluís 2021-02-23T18:43:58Z2021-02-23T18:43:58Z2020-09-302021-02-08T10:33:13Z Mammalian I kappa B proteins (I kappa Bs) exert their main function as negative regulators of NF-kappa B, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for I kappa Bs has been shown to affect stemness and cell differentiation. However, the involvement of NF-kappa B in this function has not been excluded. NFKI-1 and IKB-1 are I kappa B homologs in Caenorhabditis elegans, which lacks NF-kappa B nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans I kappa Bs in chromatin regulation. Further supporting this possibility (1) we detected NFKI-1 in the nucleus of cells; (2) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (3) and associate with chromatin in vivo, and (4) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral I kappa B inhibitors modulate Polycomb activity at specific gene subsets with an impact on development. cc by (c) Brena et al., 2020 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Anàlisi de proteïnes Nematodes Analysis of proteins Nematodes Ancestral function ofInhibitors-of-kappaB regulates Caenorhabditis elegans development info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion