2026-04-13T05:40:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1738062025-11-20T15:09:22Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Rubín García, María author Vitelli Storelli, Facundo author Molina de la Torre, Antonio José author Zamora-Ros, Raul author Aragonès Sanz, Núria author Adarnaz, Eva author Castaño-Vinyals, Gemma author Obón Santacana, Mireia author Gómez Acebo, Inés author Molina Barceló, Ana author Fernández Tardón, Guillermo author Jiménez Moleón, José Juan author Alguacil, Juan author Chirlaque, María Dolores author Toledo Atucha, Estefanía author Pérez Gómez, Beatriz author Pollán, Marina author Kogevinas, Manolis author Martín Sánchez, Vicente author 2021-02-10T09:04:25Z 2021-02-10T09:04:25Z 2020-11-01 2021-02-08T10:17:04Z Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results. Càncer d'estómac Nutrició Epidemiologia Stomach cancer Nutrition Epidemiology Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain