2026-04-14T02:31:24Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1737302025-11-19T10:41:03Zcom_2072_1057col_2072_478815col_2072_478917

00925njm 22002777a 4500 dc Cano Fernández, Amanda author Ettcheto Arriola, Miren author Espina García, Marta author Auladell i Costa, M. Carme author Folch López, Jaume author Kühne, Britta A. author Barenys Espadaler, Marta author Sánchez-López, E. (Elena) author Souto, Eliana B. author García López, María Luisa author Turowski, Patrick author Camins Espuny, Antoni author 2021-02-08T11:02:12Z 2022-01-07T06:10:18Z 2021-01-07 2021-02-08T11:02:13Z Huntington's disease (HD) is a debilitating neurodegenerative disease that affects around 5-10/100,000 individuals in developed countries. It is caused by genetic alterations in the huntingtin (htt) gene. Efforts are being made to find treatments which will correct the genetic alterations or their pathophysiological consequences associated with HD,3 however none of these options are yet available to patients. Thus, therapies that address and ameliorate the symptomatology of HD, which include motor dysfunction and a wide range of behavioural disturbances, are also needed. Epigallocatechin-3-gallate (EGCG) is a powerful compound extracted from the green tea plant that may possess beneficial effects for HD patients, but whose therapeutic success is limited because of its chemical instability. Here, we show that protective encapsulation of EGCG rendered it much more efficient in attenuating motor deficits and depression-like behaviour in a mice model of HD-like neurodegeneration. Importantly, behavioural improvement was also associated with a reduction of neuronal damage. These results, together with our previous findings using nanoparticle-encapsulated EGCG in mouse models of Alzheimer's disease and epilepsy, highlight their potential effectiveness for symptomatic treatment of neurodegenerative diseases. Nanopartícules Desenvolupament de medicaments Malalties neurodegeneratives Nanoparticles Drug development Neurodegenerative Diseases Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticles mitigate striatal pathology and motor deficits in 3-nitropropionic acid intoxicated mice