2026-04-13T01:48:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1730712026-02-20T06:33:11Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Heath, Alicia K. author Muller, David C. author van den Brandt, Piet A. author Papadimitriou, Nikos author Critselis, Elena author Gunter, Marc J. author Vineis, Paolo author Weiderpass, Elisabete author Fagherazzi, Guy author Boeing, Heiner author Ferrari, Pietro author Olsen, Anja author Tjønneland, Anne author Arveux, Patrick author Boutron-Ruault, Marie-Christine author Mancini, Francesca Romana author Kühn, Tilman author Turzanski Fortner, Renée author Schulze, Matthias B. author Karakatsani, Anna author Thriskos, Paschalis author Trichopoulou, Antonia author Masala, Giovanna author Contiero, Paolo author Ricceri, Fulvio author Panico, Salvatore author Bueno de Mesquita, H. Bas author Bakker, Marije F. author van Gils, Carla H. author Olsen, Karina Standahl author Skeie, Guri author Lasheras, Cristina author Agudo, Antonio author Rodríguez Barranco, Miguel author Sánchez, María José author Amiano, Pilar author Chirlaque, María Dolores author Barricarte, Aurelio author Drake, Isabel author Ericson, Ulrika author Johansson, Ingegerd author Winkvist, Anna author Key, Tim author Freisling, Heinz author His, Mathilde author Huybrechts, Inge author Christakoudi, Sofia author Ellingjord-Dale, Merete author Riboli, Elio author Tsilidis, Konstantinos K. author Tzoulaki, Ioanna author 2021-01-11T17:47:37Z 2021-01-11T17:47:37Z 2020-01-13 2020-12-21T13:19:23Z Background: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association between intake of 92 foods and nutrients and breast cancer risk using a nutrient-wide association study. Methods: Using data from 272,098 women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we assessed dietary intake of 92 foods and nutrients estimated by dietary questionnaires. Cox regression was used to quantify the association between each food/nutrient and risk of breast cancer. A false discovery rate (FDR) of 0.05 was used to select the set of foods and nutrients to be replicated in the independent Netherlands Cohort Study (NLCS). Results: Six foods and nutrients were identified as associated with risk of breast cancer in the EPIC study (10,979 cases). Higher intake of alcohol overall was associated with a higher risk of breast cancer (hazard ratio (HR) for a 1 SD increment in intake = 1.05, 95% CI 1.03–1.07), as was beer/cider intake and wine intake (HRs per 1 SD increment = 1.05, 95% CI 1.03–1.06 and 1.04, 95% CI 1.02–1.06, respectively), whereas higher intakes of fibre, apple/ pear, and carbohydrates were associated with a lower risk of breast cancer (HRs per 1 SD increment = 0.96, 95% CI 0.94–0.98; 0.96, 95% CI 0.94–0.99; and 0.96, 95% CI 0.95–0.98, respectively). When evaluated in the NLCS (2368 cases), estimates for each of these foods and nutrients were similar in magnitude and direction, with the exception of beer/cider intake, which was not associated with risk in the NLCS. Conclusions: Our findings confirm a positive association of alcohol consumption and suggest an inverse association of dietary fibre and possibly fruit intake with breast cancer risk. Càncer de mama Nutrició Breast cancer Nutrition Nutrient-wide association study of 92 foods and nutrients and breast cancer risk