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Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study Leurs, C. E. Twaalfhoven, H. Lissenberg-Witte, B. I. van Pesch, V. Dujmovic, Irena Drulovic, J. Castellazzi, M. Bellini, T. Pugliatti, M. Kuhle, J. Villar, Luisa M. Álvarez Cermeño, José C. Alvarez Lafuente, R. Hegen, H. Deisenhammer, F. Walchhofer, L. M. Thouvenot, E. Comabella, Manuel Montalbán Gairín, Xavier Saiz Hinarejos, Albert Puma, D. La Vercammen, M. Vanopdenbosch, L. Uitdehaag, B. M. J. Killestein, J. Bridel, C. Teunissen, C. Esclerosi múltiple Marcadors bioquímics Multiple sclerosis Biochemical markers Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mix- ture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI=4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. 2021-01-11T14:15:43Z 2021-01-11T14:15:43Z 2020 2021-01-11T14:15:43Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1177/1352458519845844 Multiple Sclerosis Journal, 2020, vol. 26, num. 8, p. 912-923 https://doi.org/10.1177/1352458519845844 cc by-nc (c) Leurs et al., 2020 http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess SAGE Publications Articles publicats en revistes (Medicina)