2026-04-14T08:35:11Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1730692025-12-04T19:18:20Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921
Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study
Leurs, C. E.
Twaalfhoven, H.
Lissenberg-Witte, B. I.
van Pesch, V.
Dujmovic, Irena
Drulovic, J.
Castellazzi, M.
Bellini, T.
Pugliatti, M.
Kuhle, J.
Villar, Luisa M.
Álvarez Cermeño, José C.
Alvarez Lafuente, R.
Hegen, H.
Deisenhammer, F.
Walchhofer, L. M.
Thouvenot, E.
Comabella, Manuel
Montalbán Gairín, Xavier
Saiz Hinarejos, Albert
Puma, D. La
Vercammen, M.
Vanopdenbosch, L.
Uitdehaag, B. M. J.
Killestein, J.
Bridel, C.
Teunissen, C.
Esclerosi múltiple
Marcadors bioquímics
Multiple sclerosis
Biochemical markers
Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mix- ture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI=4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS.
2021-01-11T14:15:43Z
2021-01-11T14:15:43Z
2020
2021-01-11T14:15:43Z
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
1352-4585
https://hdl.handle.net/2445/173069
690300
31066634
eng
Reproducció del document publicat a: https://doi.org/10.1177/1352458519845844
Multiple Sclerosis Journal, 2020, vol. 26, num. 8, p. 912-923
https://doi.org/10.1177/1352458519845844
cc by-nc (c) Leurs et al., 2020
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
12 p.
application/pdf
SAGE Publications
Articles publicats en revistes (Medicina)