2026-04-17T14:36:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1730692025-12-04T19:18:20Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Leurs, C. E. author Twaalfhoven, H. author Lissenberg-Witte, B. I. author van Pesch, V. author Dujmovic, Irena author Drulovic, J. author Castellazzi, M. author Bellini, T. author Pugliatti, M. author Kuhle, J. author Villar, Luisa M. author Álvarez Cermeño, José C. author Alvarez Lafuente, R. author Hegen, H. author Deisenhammer, F. author Walchhofer, L. M. author Thouvenot, E. author Comabella, Manuel author Montalbán Gairín, Xavier author Saiz Hinarejos, Albert author Puma, D. La author Vercammen, M. author Vanopdenbosch, L. author Uitdehaag, B. M. J. author Killestein, J. author Bridel, C. author Teunissen, C. author 2021-01-11T14:15:43Z 2021-01-11T14:15:43Z 2020 2021-01-11T14:15:43Z Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mix- ture modeling was used to define a cut-off for KFLC and LFLC indexes. Results: The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI=4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB. Conclusion: Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. Esclerosi múltiple Marcadors bioquímics Multiple sclerosis Biochemical markers Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study