2026-04-17T05:40:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1726812025-11-19T11:04:25Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Storniolo, Carolina Emilia author Sacanella, Ignasi author Lamuela Raventós, Rosa Ma. author Moreno Aznárez, Juan José author 2020-12-11T13:14:14Z 2020-12-11T13:14:14Z 2020-07-09 2020-12-11T13:14:14Z Mediterranean diet (MD) is associated with a low incidence of colorectal cancer, but the specific dietary constituents involved and mechanisms related to these beneficial effects are still sparse. Sofrito, a traditional MD preparation, is a mix of foods characteristics of MD such as tomato, onion, garlic, and extra virgin olive oil, which contains many bioactive phenolic compounds and carotenoids. The aim of the present study was to determine the action of these components of sofrito on reactive oxygen species and eicosanoid production as well as the cell growth/cell cycle in adenocarcinoma cell cultures. We observed that hydroxytyrosol, naringenin, naringenin glucuronide, and to a lesser extent lycopene and β-carotene modulate these events in Caco-2 cell cultures. Interestingly, we also found an additive action of these bioactive compounds that could explain these biological actions on concentrations reached after the consumption of a traditional MD. Tomàquets Aterosclerosi Cuina mediterrània Tomatoes Atherosclerosis Mediterranean cooking Bioactive Compounds of Mediterranean Cooked Tomato Sauce (Sofrito) Modulate Intestinal Epithelial Cancer Cell Growth Through Oxidative Stress/Arachidonic Acid Cascade Regulation