2026-04-13T13:42:05Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1726102025-12-05T09:33:45Zcom_2072_1057col_2072_478799col_2072_478917
RECERCAT
author
Afelik, Solomon
author
Rovira, Meritxell
2020-12-09T14:38:40Z2020-12-09T14:38:40Z2017-05-162020-12-09T14:38:40Z
Diabetes mellitus is a metabolic disorder characterized by dysfunction, loss, or insufficient mass of β cells. The main function of β cells is to produce and secrete insulin, the hormone responsible for the regulation of blood glucose levels. Type 1 diabetes (T1D) results from autoimmune destruction of β cells, while type 2 diabetes (T2D) mostly results from β-cell dysfunction or peripheral tissue resistance to insulin, often culminating in β-cell death. Thus, both forms of diabetes can benefit from restoration of β-cell mass. Currently, islet transplantation is the only way to provide new β cells to diabetic patients, but the scarcity of compatible cadaveric donors makes this approach available to only few patients; moreover, it requires lifelong immune suppression.
cc-by (c) Afelik, Solomon et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Pàncrees
Cèl·lules B
Gens
Pancreas
B cells
Genes
Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved.
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion