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Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms - an update on the evidence Castelo-Branco Flores, Camil Gambacciani, M. Cano, Antonio Minkin, M.J. Rachoń, D. Ruan, X. Beer, A.M. Schnitker, J. Henneicke-von Zepelin, H.H. Pickartz, S. Menopausa Ressenyes sistemàtiques (Investigació mèdica) Fitoteràpia Menopause Systematic reviews (Medical research) Phytotherapy A systematic literature search revealed 35 clinical studies and one meta-analysis comprising 43,759 women, of which 13,096 were treated with isopropanolic Cimicifuga racemosa extract (iCR). Compared to placebo, iCR was significantly superior for treating neurovegetative and psychological menopausal symptoms, with a standardized mean difference of 0.694 in favor of iCR (p<0.0001). Effect sizes were larger when higher dosages of iCR as monotherapy or in combination with St. John's wort (Hypericum perforatum [HP]) were given ( 1.020 and 0.999, respectively), suggesting a dose-depend- ency. For psychological symptoms, the iCRþHP combination was superior to iCR monotherapy. Efficacy of iCR was comparable to low-dose transdermal estradiol or tibolone. Yet, due to its better tol- erability, iCR had a significantly better benefit-risk profile than tibolone. Treatment with iCR/iCRþHP was well tolerated with few minor adverse events, with a frequency comparable to placebo. The clin- ical data did not reveal any evidence of hepatotoxicity. Hormone levels remained unchanged and estrogen-sensitive tissues (e.g. breast, endometrium) were unaffected by iCR treatment. As benefits clearly outweigh risks, iCR/iCRþHP should be recommended as an evidence-based treatment option for natural climacteric symptoms. With its good safety profile in general and at estrogen-sensitive organs, iCR as a non-hormonal herbal therapy can also be used in patients with hormone-dependent diseases who suffer from iatrogenic climacteric symptoms. 2020-11-30T19:44:02Z 2020-10-06 2020-11-30T19:44:02Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.1080/13697137.2020.1820477 Climacteric, 2020 https://doi.org/10.1080/13697137.2020.1820477 (c) The Author(s), 2020 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Taylor and Francis Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)