2026-04-17T12:35:59Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1721662025-12-05T09:22:35Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917
RECERCAT
author
Schneider, Taiane
author
Martinez-Martinez, Arturo
author
Cubillos Rojas, Mónica
author
Bartrons Bach, Ramon
author
Ventura Pujol, Francesc
author
Rosa López, José Luis
2020-11-18T07:58:55Z2020-11-18T07:58:55Z2019-06-182020-11-18T07:58:56Z
Ubiquitin ligases regulate numerous cellular processes, including tissue homeostasis, cellular metabolism, and cell cycle progression. These enzymes recognize, interact with and ubiquitylate specific substrates. Homologous to the E6-AP carboxyl terminus (HECT) and regulator of chromosome condensation 1 (RCC1)-like domain-containing proteins (HERCs) belong to the family of HECT ubiquitin ligases. There are six human HERCs which can be divided into two subgroups: large HERCs (HERC1-2) and small HERCs (HERC3-6). Alterations in the function of large HERCs are associated with serious pathologies such as neurological disorders. Mutations in human HERC1 have been associated with overgrowth, intellectual disability and some autistic features; while mutations in HERC2 have been identified as the cause of a neurodevelopmental disorder with similarities to Angelman syndrome and autism.
cc-by (c) Schneider, Taiane et al., 2019 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Tumors
Proteïnes supressores de tumors
Genètica
Tumors
Tumor suppressor protein
Genetics
Large HERCs function as tumor suppressors
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion